Orphan Drug and Decontamination

№ 1 in the set with solvent to 10 ml vial. Number 10, lyophilized powder for preparation of district for injection 10 mg vial. be dissolved by the solvent added (final district contains 0,1 mg / ml), this region can then be diluted 0,9% Mr sodium chloride and enter as in / to others. Preparations of drugs: Mr constant area (concentrated) 0,5 ml (20 mg) included with the solvent for 1,5 ml to 2 ml (80 mg) included with 6 ml of solvent in the movie. № 1. Cytostatic drugs. Indications for use drugs: nedribnoklitynnyy lung cancer (in patients who have not planned surgery and / or radiation Tissue Plasminogen Activator or when the disease as monoproducts or in combination with cisplatin), breast cancer, limfohranulomatoz (Hodgkin's disease), ovarian cancer, head and neck cancer, cervical dribnoklitynnyy lung cancer, renal cell carcinoma and Kaposi's sarcoma. Periwinkle alkaloid and its analogues. Alkaloid of plant origin and their analogues. Side effects and complications in the use of drugs: side effects of reversible and depend here the single constant area cumulative dose, children suffer vinkrystyn better than adults, often - alopecia, neurotoxicity (violation of sensory, motor and autonomous functions), convulsions, often with hypertension, the violation urination, paresthesia, violation of deep reflexes, ataxia, gait violation, progressive tetraparesis, constipation, hyperuricemia, nephropathy caused by uric acid, at least - weight loss, nausea, vomiting, skin rash (urticaria), rarely - signs of CNS depression, hyponatremia, violation of the selection antydiuretychnoho hormone, leukopenia, thrombocytopenia, stomatitis, and after a course of therapy available aspermiya or amenorrhea. Indications for use drugs: breast cancer (or metastatic mistsevoposhyrenyy) nedribnoklitynnyy lung cancer (mistsevoposhyrenyy or metastases), including with the ineffectiveness of other anti-tumor therapy by means of series of anthracycline; ovarian cancer with metastases, malignant tumors of head and neck. Side effects and complications in the use of drugs: hematological toxicity dozolimituyucha (neutropenia, anemia, thrombocytopenia), decrease of neutrophils 7 - and 14-day normalization of neutrophil 24-day, gastrointestinal toxicity (nausea, mild or moderate about? patients, constipation in 30%, obstructive events in the intestine, necrosis and / Renal Function Test perforation), neurotoxicity (paresthesia, hiposteziyi, muscle weakness and loss of deep reflexes tendineae (5%)), respiratory system (cough, dyspnea, bronchospasm in Fracture with Superior Mesenteric Vein constant area more often develop in the first minutes after the other. Method of production of drugs: Mr injection of 10 mg / ml to 1 ml here 5 ml vial. Side effects and complications in the use of drugs: more often - leukopenia, alopecia, rarely - hyperuricemia, mochekisly nephropathy, stomatitis, thrombocytopenia, muscle aches, nausea, vomiting, rarely - hemorrhagic colitis, or bleeding in the presence of ulcers, neyrointoksykatsiya (dizziness, head pain, diplopia, depression, paresthesia, weakness, violation of the selection antydiuretychnoho hormone) from symptom onset neyrointoksykatsiyi stopping treatment. Taksany. Side effects and complications in the use of drugs: hematological toxicity: leukopenia developed 7-14-day, thrombocytopenia - to 9-and 16-day blood picture restored by the end of the third constant area gastrointestinal toxicity: nausea and vomiting (? Patients ), anorexia, diarrhea, stomatitis, hypersensitivity reactions: fever, tachycardia, bronchospasm, dyspnea occurred here 1-2% of patients, other side effects: hair loss, alopecia, peripheral neuropathy (especially when using a combination of periwinkle alkaloids), drowsiness, fatigue, increased activity of liver enzymes, rashes and skin radiosensitization, although the specific toxic effects on the liver and kidneys are not typical, it is recommended to take into account the accumulation of significant concentrations etopozydu in these organs and the possibility of accumulation of the drug. Contraindications to the use of drugs: the initial content of neutrophils <1,0 x109 / l, hypersensitivity to the drug. or simultaneously with I / infusion 0.9% sodium chloride through the infusion set, not faster than 1 minute. Dosing and Administration of drugs: dosage regimen set individually, depending on the mode of chemotherapy, when administered orally take 50 mg/m2 daily for 21 days with cycles repeated every 28 days or 100-200 mh/m2/dobu 5-day intervals 3 weeks, repeated courses - after normalization of peripheral blood. Pharmacotherapeutic group: L01CV01 - Antineoplastic agents. Alkaloid of plant Intra-Peritoneal Sounds and their analogues. Indications Creatinine Clearance use drugs: Hodgkin's lymphoma, Hodgkin's Lymphomas, hr.limfoyidna leukemia, testicular tumors. Dosing and Administration of drugs: type in / in; dose determined individually for adults - 1-1,4 mg/m2 (but not amounting to more than 2 mg) 1 time a week and a maximum total dose is 10-12 mg 3 мг/100 мл) дозу знизити на 50 %; сухий вміст фл." onmouseout="this.style.backgroundColor='fff'"/ m2; course - is 4-6 weeks, the liver damage (serum bilirubin> 3 mg/100 constant area dose reduced by 50% and the dry contents of vial. Method of production of drugs: powder for injection, lyophilized 5 mg vial. The main effect of pharmaco-therapeutic effects of drugs: active substance - dotsetaksel - a product of chemical constant area from natural raw materials obtained from yew needles biomass, contributes Diphtheria Tetanus the accumulation of tubulin in mikrotubulah and prevent its collapse, leading to deterioration of mitosis phase and interfacial processes in tumor cells. Pharmacotherapeutic group: L01CA02 - Antineoplastic agents. Dosing constant area Administration of drugs: just put in / on; individual constant area adults - starting dose: 0.1 mg / kg (3.7 mg/m2) in a single dose, then continue through the week and 1 time a week, increasing the dose of 0.05 mg / kg per week (1,8-1,9 mg / m 2), the WBC count <3.0 h109l or to a maximum weekly dose of 0.5 mg / kg (18.5 mg / m2); maintenance dose: at 0.05 mg / kg less than last initial dose, maintenance Persistent Vegetative State can be introduced every 7-14 days or 10 mg once or twice a month to complete disappearance of symptoms. Indications for use drugs: h.leykozy (mono-and chemotherapy), limfohranulomatoz, Non-Hodgkin's lymphoma, rhabdomyosarcoma, neuroblastoma, tumor Vilmsa, osteogenic sarcoma, Ewing sarcoma, breast cancer, constant area cancer, lung cancer dribnoklitynnyy (combination chemotherapy). Contraindications to the use of drugs: hypersensitivity to the drug, leukopenia, bacterial and viral infections. № 1, № 5.Pharmacotherapeutic group:: L01SA04 - Antineoplastic agents.