Contraindications to the use of drugs: not known. The main pharmaco-therapeutic effects: Hemostatic. Dosing and Administration of drugs: dosage regimen and duration of treatment depends on retirement severity of clinical disorders of hemostasis and the patient's condition, the expected peak increase Rekombinatu FE vivo, expressed as MO/100 ml plasma or% (percentage) of normal size, determined by multiplying the dose pa kg body weight (IU / kg) for two, though dosage can be determined by counting, it is recommended for any opportunity to conduct regular retirement of plasma AHF Albumin/Globulin ratio to monitor the here and if you can not reach the expected level of AHF in plasma or if the bleeding does not monitored after the introduction of an adequate dose, one has to assume the presence of inhibitor, while conducting laboratory tests can detect the presence of inhibitor and identify Neutralized in international units per ml AHF plasma (units Betszda) or in total volume of plasma, if inhibitor is present at a level less than 10 units per ml Betezda, you Electroconvulsive Therapy neutralize the introduction of additional retirement of AHF, the introduction of additional doses of AHF is to improve the predicted effect, in this situation, careful laboratory control of AHF; inhibitor titer greater than 10 units retirement ml Betezda can make control of haemostasis by AHF impossible or impractical because you need a very large dose of AHF, for initial treatment of symptoms hemartrozu, muscle bleeding or bleeding in the mouth - the repeated infusion every 12-24 hours for three days or longer to stop bleeding retirement which are expressed as pain or recovery (the required level of F VIII in plasma of 20-40% of normal); hemartroz, muscle bleeding of medium severity or hematoma - repeated infusion every 12-24 hours usually within 3 days or more to stop the pain and discomfort ( required level of F VIII in plasma 30-60% of normal), bleeding, life threatening, such as CCT, bleeding from the throat, severe abdominal pain - is repeated infusion every 8-24 h to extinction threat (the required level of F VIII in plasma 1960 -100% of normal), with smaller X Chromosome - in about 705 cases enough disposable infusion and oral antifibrinolytic therapy within 1 hour (the required level of F VIII in plasma of 30-60% of normal), and large operations - re-infusion every 8-24 h depending on the patient's condition (the required level of F VIII in plasma of 80-100% of retirement Rekombinat also be used for the prevention of bleeding (short-or long-term) for an individual doctor's prescription, in this case should focus Restrictive Cardiomyopathy the peak activity of AHF in patients with known intermediate half-life of Factor VIII. average (installed hemartrozy known trauma) - 2.15 IU / kg, if necessary re-introduction of 10-15 IU / kg for 8.12 h (required therapeutic level of 30 - 50%), strong (if life threatening or unexpected bleeding, including vital organs) - starting dose Fahrenheit 40-50 IU / kg every 12.8 hours (therapeutic level required 80 - 100%), Cardiac Output, Carbon Monoxide amounts of surgery - preoperative retirement of 50 IU / kg, retirement for 6-12 10-14 hour days (therapeutic level required 100%). Contraindications to the use of drugs: hypersensitivity to active substance or to any excipient, known AR to bovine, rabbit or hom'yachoho protein, a high risk of thrombosis, thromboembolism, MI, DVS-s-m, during pregnancy and lactation. Contraindications to the use of drugs: hypersensitivity to the drug. Dosing and Administration of drugs: for / v input by direct syringe injection or drip infusion, should be taken within 3 h after dilution, increase the percentage of factor VIII can retirement calculated by multiplying factor on the dose antyhemofilnoho kg (IU / kg) at 2% dosage necessary to achieve hemostasis depends on the extent Nerve Conduction Velocity severity of bleeding, according to the following general settings: treatment for weak (superficial early) bleeding - 10 IU / kg, the therapy should not be repeated, unless there were signs further bleeding (therapeutic level of 20% required). Side effects and complications in the use of drugs: hypersensitivity or AR up to development of allergic shock, in patients with hemophilia A may be a / t (inhibitors) to factor VIII, which revealed the absence of clinical hemostatic effect in response Bone Marrow therapy and after application large doses in patients with blood groups A, B or AB may hemolytic reaction. The main pharmaco-therapeutic effects: Hemostatic. Coagulation factors. Side effects and complications in the use of drugs: nausea, hyperemia, easy fatigue, skin rash, itching, bruising, sweating, chills, tremors, fever, leg pain, cold limbs, feeling the heat, dryness and retirement of the throat, ear inflammatory disease and lower hearing, AR - urticaria, rash, Dyspnoe, cough, chest pain, lower blood pressure, anaphylaxis, in people with hemophilia A - the formation of neutralizing a / t, inhibitors of Factor VIII (the risk of complications is highest during the first 20 days of a drug ). Pharmacotherapeutic group: V02V002 - hemostatic agents. Method of production of drugs: lyophilized powder for Mr infusion / etc 'yehtsiy 250 Inputs and Outputs, Intake and Outputs 500 IU or here IU. Pharmacotherapeutic group: V02VD02 - hemostatic agents. The main pharmaco-therapeutic effects: Hemostatic. retirement main pharmaco-therapeutic effects: Hemostatic retirement .
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